Here are some more examples of marginal readings that give a somewhat different sense than the reading in the main text. I have highlighted the words in the regular text in orange, and the reading from the margin in green and added my own comment on the difference.

Genesis 4:26 – And to Seth, to him also there was born a son; and he called his name Enos: then began men to call upon the name of the LORD.
Margin: to call themselves by the Name of the LORD
This is not when people first began to pray, but the time when there began to be a lineage of people who called themselves the people of the Lord to distinguish themselves from the lineage of Cain.

Psalm 121:1 I will lift up mine eyes unto the hills, from whence cometh my help.
Margin: Shall I lift up mine eyes to the hills? whence should my help come?
Hebrew has no punctuation; but this verse is a question. Our help comes from God, not from the hills.

Isaiah 2:12 -16 For the day of the LORD of hosts shall be upon every one that is proud and lofty, and upon every one that is lifted up; and he shall be brought low: . . .and upon all pleasant pictures.
Margin: pictures of desire
God is not against something just because it is nice to look at. But when our desire is set on a picture rather than on God, He will judge us.

2 Corinthians 10:5 Casting down imaginations, and every high thing
Margin: reasonings
This seems just a little stronger to me.

Colossians 2:18 Let no man beguile you of your reward
Margin: judge against you
in a voluntary humility and worshipping of angels,
Margin: Gr. being a voluntary in humility
Voluntary is of French origin and means of one’s own will. That is clearer in the marginal reading.

1 Peter 2:9 But ye are a chosen generation, a royal priesthood, an holy nation, a peculiar people;
Margin: a purchased people
Peculiar has shifted in meaning since the translation was made, purchased is still very clear.

There are not a lot of instances like this, and the meaning is usually not very different. The translators were men of great learning, had access to texts in the original languages and translations into many others. There is a portrait of Lancelot Andrewes, the lead translator, in my post of four days ago. Andrewes was fluent in 15 modern and 6 ancient languages. Even with all this learning, the translators were careful not to let their own opinions override the Word of God, thus the reason for the alternate readings in the margin.

What do you think? Do examples like this prompt you to take a closer look at these verses to consider what the message really is?